PROF. WONG, Chris Kong Chu (黃港住)

ckcwong

B.Sc., HKBU; Ph.D., HKU

Professor and Head of Deparment of Biology,

Director of Croucher Institute for Environmental Sciences,

Hong Kong Baptist University

Rm. T704A; (852) 3411-7053

Email: ckcwong@hkbu.edu.hk

CURRENT RESEARCH INTERESTS

Osmosensing mechanisms and osmoregulatory functions of fish gill cells.
Functional characterization of human glycoprotein hormones, STC1 and STC2 in carcinogenesis.
Environmental contamination and mechanistic actions of emerging chemical pollutants.

MAJOR EXTERNAL RESEARCH GRANTS (PRINCIPAL INVESTIGATOR)

General Research Fund (Hong Kong) 2010-13, The Identification of Stanniocalcin-1 Target Cells and the Characterization of the In-Situ Ca2+-Sensing and Transport Mechanisms in Gill Epithelial Cells of Japanese Eels.
General Research Fund (Hong Kong) 2008-11, Study on the osmosensing mechanisms in gill cells of Japanese eels.
Collaborative Research Fund, CRF 2009-12, Environmental Screening, Computational and Biological Characterization of Endocrine Disruptors, in Respect to Receptor Binding, Embryo and Gonad.

SELECTED PUBLICATIONS
Molecular Endocrinology and Physiology

BHY Yeung and Chris KC Wong (2011) Stanniocalcin-1 regulates re-epithelialization in human keratinocytes. PLoS One (in press).

WKF Tse, SC Chow, KP Lai, DWT Au and Chris KC Wong (2011) Modulation of ion transporter expression in gill mitochondrion-rich cells of eels acclimated at low- Na+ or Cl- freshwater. J Exp Zool A Ecol Genet and Physiol 315(7):385-393.

SC Chow and Chris KC Wong (2011) The regulatory functions of hyperosmotic stress-induced signaling cascades to the expressions of osmotic stress transcriptional factors and osmolyte transporters in primary gill cell culture of freshwater Japanese eels. J Exp Biol 214:1264-1270.

AYS Law, BHY Yeung, LY Ching and Chris KC Wong (2011) Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. J Cell Biochem 112:2089-2096.

AYS Law, Chris KC Wong (2010) Stanniocalcin-2 Promotes Epithelial Mesenchymal Transition and Metastasis in Hypoxic Human Ovarian Cancer Cells. Exp Cell Res 316:3425-3434.

AYS Law and Chris K.C. Wong (2010) Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. Exp Cell Res 316:466-476.

AYS Law, LY Ching, KP Lai and Chris K.C. Wong (2010) Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene. Mol Cell Endocrinol. 314: 118-127.

SC Chow, LY Ching, AMF Wong and Chris KC Wong (2009) The cloning and the regulation of Na+-Cl--taurine transporter expression in gill cells of freshwater Japanese eels. J Exp Biol. 212:3205-3210.

AYS Law, KP Lai, WC Lui, and Chris KC Wong (2008) Histone deacetylase inhibitors induced-cellular apoptosis involves stanniocalcin-1 activation. Exp Cell Res 314:2975-2984.

AYS Law, KP Lai, CKM Ip, AST Wong, GF Wagner, and Chris KC Wong (2008) Epigenetic and HIF-1 Regulation of Stanniocalcin-2 Expression in Human Cancer Cells. Exp Cell Res 314:1823-1830.

Environmental and Molecular Toxicology

AYS Law, X Wei, XW Zhang, NK Mak, KC Cheung, MH Wong, J Giesy and Chris KC Wong (2011) Biological analysis of endocrine-disrupting chemicals in animal meats from the Pearl River Delta, China. J Expo Sci Environ Epidemiol (in press).

YG Zhao, HT Wan, AYS Law, X Wei, YQ Huang, J Giesy, MH Wong and Chris KC Wong (2011) Risk Assessment for human consumption of perfluorinated compound-contaminated freshwater and marine fish from Hong Kong and Xiamen. Chemosphere (in press).

BHY Yeung, HT Wan, AYS Law and Chris KC Wong (2011) Endocrine disrupting chemicals: multiple effects on testicular signaling and spermatogenesis. Spermatogenesis 1(3):231-239 (Review article).

X Wei, YQ Huang, MH Wong, JP Giesy and Chris KC Wong (2011) Assessment of risk to humans of bisphenol A in marine and freshwater fish from Pearl River Delta, China. Chemosphere 85:122-128.

X Zhang, H Chang, S Wiseman, Y He, E Higley, P Jones, Chris KC Wong, A Al-Khedhairy, J Giesy and M Hecker (2011) Bisphenol A disrupts steroidogenesis in human H295R cells. Toxicol Sci 121:320-327.

HT Wan, YG Zhao, MH Wong, CKF Lee, WSB Yeung, JP Giesy and Chris KC Wong (2011) Testicular signaling is the potential target of PFOS-mediated subfertility in male mice. Biol Reprod 84:1016-1023.

X Wei, CKF Lee, WSB Yeung, John P Giesy, MH Wong, XW Zhang, M Hecker and Chris KC Wong (2011) Effect of Perinatal and Postnatal Bisphenol A Exposure to the Regulatory Circuits at the hypothalamus-pituitary-gonadal axis of CD-1 Mice. Reproductive Toxicol 31:409-417.

HS Wang, J Du, KL Ho, HM Leung, MH Lam, JP Giesy, Chris KC Wong* and MH Wong* (2011) Exposure of Hong Kong residents to PBDEs and their structure analogues through market fish consumption. J Hazard Mater 192(1):374-380.

AO Leung, J Zheng, CK Yu, WK Liu, Chris KC Wong, ZW Cai and MH Wong (2011) Polybrominated diphenyl ethers and polychlorinated dibenzo-p-dioxins and dibenzofurans in surface dust at an E-waste processing site in southeast China. Environ Sci Technol 45(13):5775-5782.

X Wei, LY Ching, SH Cheng, MH Wong, Chris KC Wong (2010) The detection of dioxin- and estrogenic-like pollutants in marine and freshwater fishes cultivated in Pearl River Delta, China. Environ Pollution 158:2302-2309.